As ever, tempus fugit. I have finally accepted I will not be keeping up with the Ebola literature any time soon. So I am posting three more lists of links, covering April, May and June of 2016, and then leaving you all to run your own PubMed and GoogleScholar alerts (I set mine for delivery weekly and whenever Google wants to send me something respectively). After that, it is back to occasional posts on the social determinants of HIV, TB, etc (i.e. my day job). It has been a privilege learning so much about an awful outbreak and the phenomenal efforts made by so many to fight it. Thank you for dropping by and motivating me to stay focused, and sometimes even up-to-date.
First up, things indexed in April 2016.
Therapeutics and Vaccines
- Jake Dunning, Foday Sahr and colleagues report the TKM-130803 trial from early 2015, which was stopped for futility based on non-improved survival vs historic controls. Experimental Treatment of Ebola Virus Disease with TKM-130803: A Single-Arm Phase 2 Clinical Trial.
- Iain Milligan and colleagues report on safety data from a phase-I trial on Ad26.ZEBOV delivered via MVA-BN-Filo. Safety and Immunogenicity of Novel Adenovirus Type 26– and Modified Vaccinia Ankara–Vectored Ebola Vaccines: A Randomized Clinical Trial.
- Hilary Bower and colleagues showed no additional risk for EVD amongst 77 children in households with EVD survivors, over and above that conferred by their mothers’ history of EVD. Effects of Mother’s Illness and Breastfeeding on Risk of Ebola Virus Disease in a Cohort of Very Young Children.
- Anna Grigoryan and colleagues presented a comprehensive literature review of Mental Health and Psychosocial Aspects of Ebola Virus Disease.
- Li Wen-Gang and colleagues examined 278 EVD-suspected but negative patients at Jui hospital between November 2014 and March 2015. The etiology of Ebola virus disease-like illnesses in Ebola virusnegative patients from Sierra Leone.
Epidemic control strategies
- Rebecca Levine and colleagues describe the setting up of a contact tracing system in Kambia. Development of a Contact Tracing System for Ebola Virus Disease — Kambia District, Sierra Leone, January–February 2015.
- Christian Ahrberg and colleagues describe the early development of a hand-held point-of-care RT-PCR device. Palm-sized device for point-of-care Ebola detection.
- Jennifer Huang and colleagues describe the practicalities of using rapid diagnostic tests in the field. Baseline Assessment of the Use of Ebola Rapid Diagnostic Tests — Forécariah, Guinea, October–November 2015.
- V Cáceres and colleagues on prospective monitoring of laboratories for EVD outbreaks. Daily zero-reporting for suspect Ebola using short message service (SMS) in Guinea-Bissau.
- Huijun Xi and colleagues describe training and maintaining care in donning/doffing of protective clothing for healthcare workers. Improving health care workers’ protection against infection of Ebola hemorrhagic fever through video surveillance.
- Kimberly Gittings and Kelly Matson explored the levels of vaccine coverage required to reduce the reproductive number for Ebola below one. Establishing herd immunity against Ebola through vaccination.
- Zuiyuan Guo, Dan Xiao and colleagues present a long-term model of Ebola dynamics highlighting the risk of periodic re-eruptions (on 5-15 year cycles). Predicting and Evaluating the Epidemic Trend of Ebola Virus Disease in the 2014-2015 Outbreak and the Effects of Intervention Measures.
Health care for Ebola
- Karen Wong and colleagues describe the 6 heathcare workers given rVSV-ZEBOV or TKM-100802 as PEP in 2014 and early 2015. Use of post-exposure prophylaxis after occupational exposure to Zaire ebolavirus.
Ebola epidemic impact
- F Moisan and colleagues show modest reductions in health centre attendance during the Ebola outbreak, but highlight a reduced ability to conduct proactive surveillance for non-Ebola infections. Public health structures attendance during the Ebola outbreak in Guéckédou, Guinea.
- Timothy Uyeki and colleagues present RT-PCR and culture results from 5 men to show Ebola virus persistence in semen of male survivors at 290 and 70 days respectively.
- Lauren Bowen and colleagues made a presentation highlighting that in the PREVAIL III study of 87 survivors of Ebola Virus Disease, many have persistent neurological deficits.
- A Carrión Martín and colleagues describe social and cultural factors behind community resistance during an Ebola outbreak in a village of the Guinean Forest region, February 2015 based on observation interviews and focus group discussions.
- Jessica Spengler and colleagues provide a broad overview of the epidemic, including social and biological factors. Perspectives on West Africa Ebola Virus Disease Outbreak, 2013–2016.
- Zhilan Feng and colleagues critically evaluate the commonly used Legrand mathematical models of Ebola and discuss the consequences of its underlying assumptions.
- David Blackley and colleagues use data from two Ebola flare-ups in Liberia in 2015 to highlight reduced evolutionary rate in reemerged Ebola virus transmission chains, based on slower evolution during persistent infection.